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KMID : 1134820210500070679
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Journal of the Korean Society of Food Science and Nutrition
2021 Volume.50 No. 7 p.679 ~ p.691
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Antioxidant Activity, Skin Whitening, and Anti-Wrinkle Effects of Various Agastache rugosa Fractions
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Kim Ji-Wan
Hong Joo-Heon
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Abstract
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In this study, the antioxidant, skin whitening, and anti-wrinkle effects of fractions from Agastache rugosa were evaluated. The 70% ethanol extract of Agastache rugosa was fractionated to get n-hexane (HF), chloroform (CF), ethyl acetate (EF), n-butanol (BF), and water (WF) fractions, depending on the polarity of the solvent. Total polyphenol and flavonoid contents of the EF were the highest among 5 different fractions at 27.79 g/100 g and 39.00 g/100 g, respectively. The DPPH, ABTS radical scavenging activity, and FRAP activity of the EF at 500 μg/mL were 89.89%, 85.31%, and 2.05 μM, respectively. The ORAC value of the EF at 1,000 μg/mL was 129.33 μM TE/g. Tyrosinase, elastase, and collagenase inhibitory activity were highest in the EF at 33.16%, 27.33%, and 32.94%, respectively. The EF was better than the other fractions with respect to regeneration and protective effects against oxidative stress in L-132 cells. The protective effect in UV-irradiated human dermal fibroblasts, inhibitory effect on tyrosinase activity, and melanin production in B16F10 cells was confirmed with the EF. Thus, the obtained results suggest that Agastache rugosa fractions have potential applications as functional materials in the food industry.
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KEYWORD
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Agatache rugosa, fractions, antioxidant activity, skin whitening, anti-wrinkle effect
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